TOXICOLOGY
Toxicology testing plays a critical role in monitoring patient compliance, identifying substance use or misuse, and supporting informed treatment planning. At USA Diagnostics, we combine rapid immunoassay screening with confirmatory analysis using liquid chromatography–tandem mass spectrometry (LC-MS/MS) to deliver highly accurate and specific results.
​
Our toxicology services include:
-
Drug Class Screening for rapid preliminary assessment
-
Reflex Confirmation for any presumptive positive findings
-
Comprehensive Confirmation Panels for broad detection of substances and metabolites
LAB REQUISITIONS
SAMPLE REPORTS
OUR TOXICOLOGY TESTING
Screening Panel – Drug Classes
Our initial immunoassay drug screen detects:
-
Amphetamines
-
Barbiturates
-
Benzodiazepines
-
Cocaine
-
Ethanol (ETOH)
-
Methadone
-
Opiates
-
Oxycodone
-
Phencyclidine (PCP)
-
Tetrahydrocannabinol (THC)
​
Reflex Confirmation
If any drug class in the screen is positive, we automatically perform a targeted LC-MS/MS confirmation for that class to validate results and quantify levels.
​
Full Confirmation Panel – Analytes
Our comprehensive LC-MS/MS toxicology panel detects and confirms the following:
​
-
Barbiturates: Amobarbital, Butalbital, Phenobarbital
-
Alcohol Metabolites: Ethyl Glucuronide (ETG), Ethyl Sulfate (ETS)
-
Opiates & Opioids: Codeine, Morphine, Hydrocodone, Hydromorphone, Norhydrocodone, Oxycodone, Oxymorphone, Noroxycodone, 6-Monoacetylmorphine, Methadone, EDDP, Meperidine, Normeperidine, Fentanyl, Norfentanyl, Buprenorphine, Norbuprenorphine, Tapentadol, Tramadol, Desmethyltramadol, Naloxone, Naltrexone, Mitragynine (Kratom)
-
Benzodiazepines: Alprazolam, Hydroxyalprazolam, Clonazepam, 7-Aminoclonazepam, Diazepam, Nordiazepam, Flunitrazepam, Lorazepam, Temazepam, Oxazepam, Flurazepam, Hydroxytriazolam, Hydroxymidazolam, Zaleplon, Zolpidem, Zolpidem COOH
-
Stimulants & Related: Amphetamine, Methamphetamine, MDA, MDEA, MDMA, Phentermine, Methylphenidate, Ritalinic Acid
-
Antidepressants: Amitriptyline, Nortriptyline, Imipramine, Desipramine, Doxepin, Fluoxetine, Sertraline, Venlafaxine
-
Muscle Relaxants & Sedatives: Carisoprodol, Meprobamate, Cyclobenzaprine, Gabapentin, Pregabalin
-
Anesthetics & Dissociatives: Ketamine
-
Other Agents: OPRM1-related opioids, multiple drug metabolites for compliance monitoring
SAMPLE COLLECTION & PROCESS
Specimen Type: Urine (primary), oral fluid available for specific programs
Turnaround Time:
-
Screening results: Same day or next business day
-
Confirmation results: 1–3 business days after specimen receipt
Reporting:
-
Clear, easy-to-read reports showing detected analytes, concentrations, and cutoff levels
-
Positive confirmations include metabolite profiles for prescription compliance assessment
KIT INSTRUCTIONS
Included: Collection cup or oral fluid device, security seal, biohazard transport bag, requisition form, prepaid return label
Steps:
-
Collect specimen following chain-of-custody or standard collection protocols.
-
Secure lid and apply tamper-evident seal.
-
Label specimen with patient name, DOB, and collection date/time.
-
Complete requisition form, noting medications reported by patient.
-
Place specimen in transport bag with paperwork in outer pocket.
-
Return via prepaid courier or approved pickup.
FAQ'S
Q: What’s the difference between screening and confirmation?
A: Screening quickly detects drug classes; confirmation uses LC-MS/MS to identify and quantify specific drugs and metabolites.
​
Q: Do you automatically confirm positives?
A: Yes, through our reflex confirmation protocol.
​
Q: Can results show if a medication is being taken as prescribed?
A: Yes—metabolite patterns can indicate compliance or possible diversion.
Q: How far back can drugs be detected?
A: Detection windows vary by drug class and patient metabolism, from hours to several days or weeks.
​
Q: Is testing admissible for legal or compliance programs?
A: Yes—when collected with proper chain-of-custody procedures.

Get in Touch
Whether you’re exploring new testing options or looking for a laboratory partner you can trust, our team is here to help. Reach out to learn more about our services, onboarding process, or how USA Diagnostics can support your practice with reliable results and responsive service.
